Why DNA Fragmentation Test is vital for infertile men?

Here at IIRFT, a leading fertility training institute in India, we aspire to become the leaders in fertility education industry and remove infertility from its roots.

The DNA Fragmentation test is an effective method for measuring thousands of sperm in an ejaculate. Sperms are stained with a fluorescent probe that interacts with the DNA molecule. The fluorescence/fluorescent signal changes when the DNA is fragmented and is monitored using a flow cytometer.

The genetic cohesion of the spermatozoan is vital for desired embryo development. A high level of DNA fragmentation indicates male infertility that conventional examinations such as sperm concentrations, motility analysis and morphology assessment fail to detect.

Regardless of the assisted reproductive technology used, high levels of DNA fragmentation above the critical threshold significantly compromises with the chances of having a successful pregnancy.

  • High sperm DNA fragmentation may not affect fertilization or first and second embryo cleavage stages.
  • High sperm DNA fragmentation may impact embryo cleavage once the paternal genome switches on and subsequent blastocyst development. DNA fragmentation levels are closely correlated with IUI, IVF and ICSI, miscarriage and pregnancy rates.
  • DNA fragmentation is significantly higher in sub fertile men.
  • Men with poor semen parameters are more likely to have high DNA fragmentation.
  • High sperm DNA fragmentation is also found in men with normal semen parameters.

Our institute offers varied embryology courses in India to students who wish to nurture their skills in the field of embryology. We have a wide range of fertility courses such as Certificate Course in ART, Certificate Course in Embryology and many more.

If you have the passion to learn about state of the ART (Assisted Reproductive Technology) with cutting edge technology under the guidance of Dr. Rita Bakshi & Competent Team, Get admission now by filling the details in the section mentioned below or write us at contact@iirft.com for any query.

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